It is possible to install PI Cloud Connect on multiple nodes in the same Organization.
The PI Cloud Connect machine will need to access the PI AF server and then create the Publications. It may make sense if you have multiple PI Systems that are geographically far apart. You could install PI Cloud Connect near one PI AF server and set the Publications from that PI AF server. On another PI AF server located far away it may be prudent with latency effects to have another PI Cloud Connect node for the Publications from that PI AF server.
I would doubt that you would get any benefit from having multiple PI Cloud Connect machines pointing to the one PI AF server though.