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This indicates the website is not running. I assume this applies to both the Coresight home page as well as the Coresight admin page.
Verify that the World Wide Web Publishing Service (W3SVC) is running (locate under Windows services). If that does not resolve the error, open IIS Manager from Administrative Tools, check whether the website under which PI Coresight is installed, is running. If not running, select the website in the IIS tree, then on the right hand side select Start from the Actions window.