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Thanks for reaching out to us on PI Square! For searching in OSI's client tools, most have their own independent search components (something we're working on standardizing) with different capabilities for searching. Thus, it depends on which tool you're using whether or not you're able to search for all items that don't meet a condition.
For example in System Management Tools, there's an Advanced Search option that allows you to look for all PI points that don't have point source R
However, when looking at Datalink's search the option to search for all tags without point source R is grayed out: